Expression patterns of fibroblast growth factor 8 in the spiral ganglion of rat cochlea
نویسندگان
چکیده
Fibroblast Growth Factor 8 (FGF8) plays a critical role in promoting the growth of axons in the brain, and it may also be a potentially important regulatory factor in the auditory system. However, no report has yet studied the expression patterns of FGF8 in spiral ganglions. Therefore, we evaluated the expressions of FGF8 and its receptors in the spiral ganglion of rats’ cochleae using immunocytochemistry and Western Blot. FGF8 was found expressed in adult rats spiral ganglion of both upper and basal turn of the cochleae, specifically in the cytoplasm of the spiral ganglion neurons (SGNs), while it was not observed in the nuclei and glial cells. FGFR1 but not FGFR2 expression was present in the spiral ganglion of adult rats, suggesting that FGF8 might function through FGFR1 to exert its effects. Moreover, FGF8 protein reached its maximal expression at early stages of postnatal development and decreased in adulthood. Collectively, our study provides preliminary proof for the presence of FGF8 in the primary auditory neurons, indicating a potential role for FGF8 in modulating neuronal functions within the spiral ganglion.
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